TAS1R2

Across TCGA cell cohorts, TAS1R2 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS1R2-associated genes across cancer lineages are XCL2, PPP1R2C, and MMP27. Each is linked with TAS1R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS1R2-to-partner and partner-to-TAS1R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XCL2 grouped by TAS1R2-low versus TAS1R2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS1R2→partner) and Y-score (partner→TAS1R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	XCL2 →	+0.152	+4.095	.002	<.001	3	2
LARGE_INTESTINE	PPP1R2C →	+0.032	+2.510	<.001	.004	3	2
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	2
BLOOD_Leukemia	TMEM132C →	+0.738	+3.966	<.001	.001	3	2
SOFT_TISSUE	OR51I1 →	+0.363	+4.369	<.001	.008	3	1
SOFT_TISSUE	TEX50 →	+0.020	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

XCL2 by TAS1R2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →