TARS1

Across TCGA cell cohorts, TARS1 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TARS1-associated genes across cancer lineages are ADAM7, SH3GL2, and MAGEB4. Each is linked with TARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARS1-to-partner and partner-to-TARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by TARS1-low versus TARS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARS1→partner) and Y-score (partner→TARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAM7 →	+0.016	+3.507	<.001	.004	3	2
LARGE_INTESTINE	SH3GL2 →	+1.636	+3.252	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	GALR3 →	+0.078	+3.424	.008	.006	3	1
LARGE_INTESTINE	USO1 →	+0.659	+3.067	.001	.009	3	1
LARGE_INTESTINE	EOMES →	+0.482	+3.302	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ADAM7 by TARS1 expression — BLOOD_Leukemia

Explore this box plot interactively →