TARM1

Across TCGA cell cohorts, TARM1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TARM1-associated genes across cancer lineages are TMEM114, PRSS58, and OR4F15. Each is linked with TARM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TARM1-to-partner and partner-to-TARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM114 grouped by TARM1-low versus TARM1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARM1→partner) and Y-score (partner→TARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM114 →	+0.065	+4.977	<.001	.007	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LUNG_SCLC	OR4F15 →	+0.022	+5.029	<.001	.006	3	1
SKIN	RFX6 →	+0.053	+5.029	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TMEM114 by TARM1 expression — SKIN

Explore this box plot interactively →