TARDBP

Across TCGA cell cohorts, TARDBP mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TARDBP-associated genes across cancer lineages are AVP, UCMA, and ACOT12. Each is linked with TARDBP in more than 1 cancer types. Because this analysis shows association rather than direction, both TARDBP-to-partner and partner-to-TARDBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by TARDBP-low versus TARDBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TARDBP→partner) and Y-score (partner→TARDBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.045	+3.632	<.001	.003	3	1
LARGE_INTESTINE	UCMA →	+0.017	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ACOT12 →	+0.030	+3.994	.004	.002	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.101	+3.155	.003	.008	3	1
LARGE_INTESTINE	TAS2R60 →	+0.023	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AVP by TARDBP expression — LARGE_INTESTINE

Explore this box plot interactively →