TANK

Across TCGA pan-cancer cohorts, TANK mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TANK data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TANK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TANK expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, CCRCC, and HNSC are the cancer types where TANK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.990	0.825	<.001	40	view →
CCRCC	OS	Quartile	All	0.778	1.000	.031	5	view →
HNSC	DFS	Median	IV	0.538	0.776	.030	5	view →
LUAD	OS	Quartile	All	0.559	0.904	.035	4	view →
PDAC	OS	Median	II,III,IV	0.607	0.372	.016	3	view →
LSCC	DFS	Tertile	II,III,IV	0.461	0.761	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TANK–UCEC (DFS)

Open the UCEC breakdown →