TANK

Across TCGA pan-cancer cohorts, TANK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TANK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TANK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TANK is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

KIRC, BRCA, and HNSC are the cancer types where TANK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TANK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.609	<.001	12	view →
BRCA	All	III,IV	−0.779	<.001	8	view →
HNSC	All	III,IV	+0.561	<.001	8	view →
KICH	Female	All	−1.316	<.001	5	view →
LUSC	Male	III,IV	−0.702	.001	5	view →
STAD	All	II,III,IV	+0.514	.002	5	view →
CHOL	Male	All	+1.208	<.001	4	view →
ESCA	All	All	+0.849	.001	4	view →
KIRP	All	All	+0.294	.018	4	view →
THCA	All	All	+0.218	.012	4	view →
UCEC	All	All	−0.450	.010	2	view →
PRAD	All	All	−0.193	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TANK–KIRC

Open the KIRC breakdown →