TANK

Across TCGA patient cohorts, TANK mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TANK-associated genes across cancer lineages are EGFR_pY1068, PCNA, and ASNS. Each is linked with TANK in more than 1 cancer types. Because this analysis shows association rather than direction, both TANK-to-partner and partner-to-TANK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TANK-low versus TANK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TANK→partner) and Y-score (partner→TANK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.303	-2.415	.002	.003	3	2
UCEC	PCNA →	+0.234	+1.906	.006	.016	3	2
UCEC	ASNS →	+0.489	+2.584	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.105	-2.295	.009	.033	3	1
UCEC	eIF4E →	+0.223	+3.183	.008	.009	3	1
UCEC	A-Raf_pS299 →	-0.179	-1.700	<.001	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

EGFR_pY1068 by TANK expression — UCEC

Explore this box plot interactively →