TAGLN3

Across TCGA patient cohorts, TAGLN3 mutation is significantly associated with the RNA expression of many other genes, with 259 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAGLN3-associated genes across cancer lineages are IGLV3-31, MIR4456, and TOMM22P4. Each is linked with TAGLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAGLN3-to-partner and partner-to-TAGLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLV3-31 grouped by TAGLN3-low versus TAGLN3-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAGLN3→partner) and Y-score (partner→TAGLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	IGLV3-31 →	+0.224	+7.977	<.001	.007	3	2
LGG	MIR4456 →	+0.592	+7.977	<.001	.007	3	2
SKCM	TOMM22P4 →	+0.115	+4.594	<.001	.008	3	2
UCEC	RNU7-12P →	+0.431	+2.829	<.001	.001	3	2
LGG	MIR519E →	+0.358	+7.977	<.001	.007	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 259 associations by consensus.

IGLV3-31 by TAGLN3 expression — LGG

Explore this box plot interactively →