TAGLN2

Across TCGA patient cohorts, TAGLN2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAGLN2-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and Akt. Each is linked with TAGLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAGLN2-to-partner and partner-to-TAGLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TAGLN2-low versus TAGLN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAGLN2→partner) and Y-score (partner→TAGLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.990	.048	.036	3	1
UCEC	mTOR_pS2448 →	-0.216	-3.459	.003	.005	3	1
UCEC	Akt →	-0.336	-3.311	.003	.010	3	1
UCEC	Notch1 →	+0.255	+3.013	<.001	.018	3	1
UCEC	p27_pT198 →	+0.114	+3.459	.034	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.481	-3.446	.033	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FOXO3a_pS318_S321 by TAGLN2 expression — UCEC

Explore this box plot interactively →