TAGLN2

Across TCGA pan-cancer cohorts, TAGLN2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TAGLN2 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TAGLN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TAGLN2 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

UVM, KIRP, and BRCA are the cancer types where TAGLN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.565	0.871	<.001	123	view →
KIRP	DFS	Tertile	II,III,IV	0.464	0.835	<.001	103	view →
BRCA	OS	Median	II,III,IV	0.878	0.943	<.001	95	view →
MESO	OS	Tertile	All	0.401	0.695	<.001	64	view →
LIHC	OS	Tertile	All	0.416	0.630	<.001	64	view →
LGG	OS	Median	All	0.730	0.892	<.001	54	view →
KIRC	DFS	Tertile	All	0.801	0.918	.002	52	view →
KICH	OS	Median	II,III,IV	0.790	0.969	.005	46	view →
LAML	DFS	Quartile	All	0.401	0.755	<.001	46	view →
ACC	OS	Quartile	All	0.688	0.971	<.001	46	view →
PAAD	DFS	Quartile	All	0.224	0.488	.002	21	view →
LUAD	OS	Quartile	All	0.648	0.812	.016	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TAGLN2–UVM (OS)

Open the UVM breakdown →