TAGLN

Across TCGA patient cohorts, TAGLN mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAGLN-associated genes across cancer lineages are NF2, Fibronectin, and JNK2. Each is linked with TAGLN in more than 1 cancer types. Because this analysis shows association rather than direction, both TAGLN-to-partner and partner-to-TAGLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by TAGLN-low versus TAGLN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAGLN→partner) and Y-score (partner→TAGLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.358	+3.000	.004	.037	3	2
UCEC	Fibronectin →	-0.377	-3.000	.048	.037	3	1
UCEC	JNK2 →	+0.436	+3.000	<.001	.037	3	1
UCEC	PEA-15_pS116 →	+0.410	+3.000	.043	.037	3	1
UCEC	Rab25 →	-0.450	-3.000	.018	.037	3	1
UCEC	Annexin-1 →	+0.804	+2.827	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

NF2 by TAGLN expression — UCEC

Explore this box plot interactively →