TAGLN

Across TCGA pan-cancer cohorts, TAGLN RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TAGLN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TAGLN RNA is repressed in tumor relative to normal tissue. In most cancer types TAGLN is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and HNSC are the cancer types where TAGLN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAGLN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−3.341	<.001	11	view →
BLCA	Male	III,IV	−5.007	<.001	10	view →
HNSC	All	III,IV	+1.359	.001	8	view →
KIRP	Male	All	−2.089	<.001	7	view →
STAD	All	All	−1.860	<.001	7	view →
COAD	All	II,III,IV	−1.747	<.001	7	view →
LUSC	All	All	−1.016	<.001	7	view →
UCEC	All	III,IV	−4.793	<.001	6	view →
BRCA	All	All	−1.531	<.001	6	view →
THCA	Female	All	−0.706	<.001	6	view →
READ	All	All	−2.770	.006	2	view →
CHOL	All	All	+2.017	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TAGLN–KICH

Open the KICH breakdown →