TAF8

Across TCGA patient cohorts, TAF8 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF8-associated genes across cancer lineages are ERK2, FOXO3a, and Ku80. Each is linked with TAF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF8-to-partner and partner-to-TAF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TAF8-low versus TAF8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF8→partner) and Y-score (partner→TAF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.269	+3.000	.005	.036	3	1
UCEC	FOXO3a →	+0.120	+2.335	.018	.020	2	2
UCEC	Ku80 →	+0.270	+2.179	.023	.034	3	1
UCEC	p62 Lck ligand →	+0.458	+3.459	.005	.005	3	1
UCEC	PKC-a →	+0.495	+2.820	.015	.035	3	1
UCEC	Caspase-8 →	-0.279	-3.169	.027	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by TAF8 expression — UCEC

Explore this box plot interactively →