TAF8

Across TCGA pan-cancer cohorts, TAF8 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TAF8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TAF8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TAF8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where TAF8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAF8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.578	<.001	11	view →
THCA	Male	III,IV	−0.678	<.001	10	view →
LIHC	Female	II,III,IV	+0.880	<.001	9	view →
COAD	Male	All	+0.406	<.001	9	view →
KICH	Female	All	−0.913	<.001	7	view →
BRCA	Female	II,III,IV	−0.247	<.001	6	view →
STAD	All	II,III,IV	+0.544	.006	4	view →
CHOL	All	All	+1.505	<.001	3	view →
READ	All	All	+0.406	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TAF8–HNSC

Open the HNSC breakdown →