TAF8

Across TCGA cell cohorts, TAF8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,944 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TAF8-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Regulation of transcription initiation by RNA polymerase II, and Positive regulation of transcription initiation by RNA polymerase II. Each is linked with TAF8 in more than 12 cancer types. Because this analysis shows association rather than direction, both TAF8-to-partner and partner-to-TAF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by TAF8-low versus TAF8-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF8→partner) and Y-score (partner→TAF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of DNA-templated transcription initiation →	+0.059	+0.844	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.058	+0.708	.001	<.001	3	13
LARGE_INTESTINE	Positive regulation of transcription initiation by RNA polymerase II →	+0.060	+0.581	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.073	+0.916	<.001	<.001	3	13
PANCREAS	DNA synthesis involved in DNA repair →	+0.090	+0.897	.001	.001	3	13
SOFT_TISSUE	Protein localization to nucleus →	+0.051	+0.770	.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,944 associations by consensus.

Regulation of DNA-templated transcription initiation by TAF8 expression — LARGE_INTESTINE

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