TAF2

Across TCGA pan-cancer cohorts, TAF2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TAF2 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TAF2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TAF2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

UVM, KIRC, and MESO are the cancer types where TAF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.253	0.844	<.001	103	view →
KIRC	DFS	Median	All	0.745	0.499	<.001	73	view →
MESO	DFS	Quartile	All	0.279	0.491	.006	57	view →
ACC	DFS	Median	All	0.414	0.740	.001	53	view →
SCLC	OS	Median	III,IV	0.824	0.389	.001	49	view →
LIHC	OS	Quartile	II,III,IV	0.208	0.500	.001	40	view →
KIRP	DFS	Quartile	All	0.756	0.944	<.001	36	view →
LUSC	DFS	Median	III,IV	0.223	0.523	.001	35	view →
THCA	OS	Median	II,III,IV	0.841	0.979	.008	29	view →
CESC	DFS	Median	III,IV	0.234	0.760	.008	28	view →
UCEC	DFS	Quartile	All	0.682	0.897	<.001	24	view →
LGG	OS	Tertile	All	0.846	0.975	.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TAF2–UVM (DFS)

Open the UVM breakdown →