TAF2

Across TCGA pan-cancer cohorts, TAF2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TAF2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TAF2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TAF2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LUAD, and THCA are the cancer types where TAF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.718	<.001	12	view →
LUAD	Male	II,III,IV	+0.990	<.001	11	view →
THCA	All	II,III,IV	−0.763	<.001	9	view →
COAD	Male	All	+0.587	<.001	9	view →
STAD	Male	II,III,IV	+1.120	<.001	8	view →
LUSC	Male	II,III,IV	+0.981	<.001	8	view →
LIHC	Male	All	+0.929	<.001	8	view →
BLCA	Male	All	+0.956	<.001	6	view →
BRCA	All	II,III,IV	+0.801	<.001	6	view →
CHOL	Male	All	+1.780	<.001	4	view →
UCEC	All	III,IV	+0.833	.032	4	view →
KICH	Female	All	−0.980	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TAF2–HNSC

Open the HNSC breakdown →