TAF1A

Across TCGA patient cohorts, TAF1A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF1A-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK_pT183_Y185, and mTOR_pS2448. Each is linked with TAF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF1A-to-partner and partner-to-TAF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by TAF1A-low versus TAF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF1A→partner) and Y-score (partner→TAF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.154	-3.160	.018	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.226	-2.999	.010	.035	3	1
UCEC	mTOR_pS2448 →	-0.229	-2.986	.003	.035	3	1
UCEC	PCNA →	+0.275	+3.321	.015	.010	3	1
UCEC	TFRC →	+0.751	+3.000	.006	.036	3	1
UCEC	Bad_pS112 →	-0.230	-3.321	.018	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FOXO3a_pS318_S321 by TAF1A expression — UCEC

Explore this box plot interactively →