TAF15

Across TCGA patient cohorts, TAF15 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF15-associated genes across cancer lineages are Src_pY416, STAT3_pY705, and ASNS. Each is linked with TAF15 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF15-to-partner and partner-to-TAF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by TAF15-low versus TAF15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF15→partner) and Y-score (partner→TAF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY416 →	-0.182	-2.295	.044	.033	3	2
UCEC	STAT3_pY705 →	-0.412	-1.797	<.001	.025	3	2
UCEC	ASNS →	+0.373	+2.584	.006	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.829	+2.926	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.349	+3.614	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.094	-2.432	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Src_pY416 by TAF15 expression — UCEC

Explore this box plot interactively →