TAF15

Across TCGA cell cohorts, TAF15 mutation is significantly associated with the mutation status of many other genes, with 3,402 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TAF15-associated genes across cancer lineages are KMT2B, HECW2, and ZNF100. Each is linked with TAF15 in more than 5 cancer types. Because this analysis shows association rather than direction, both TAF15-to-partner and partner-to-TAF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT2B grouped by TAF15-low versus TAF15-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF15→partner) and Y-score (partner→TAF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KMT2B →	+2.146	+3.860	.007	.007	1	6
BLOOD_Lymphoma	HECW2 →	+2.938	+3.169	.003	.003	1	5
LUNG_SCLC	ZNF100 →	+2.870	+3.199	.003	.003	1	5
BLOOD_Lymphoma	CCDC88A →	+5.108	+3.847	.001	.001	1	4
BLOOD_Leukemia	PHF20L1 →	+4.050	+3.870	.002	.002	1	4
BLOOD_Leukemia	KIF1A →	+3.565	+4.531	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,402 associations by consensus.

KMT2B by TAF15 expression — SKIN

Explore this box plot interactively →