TAF1

Across TCGA patient cohorts, TAF1 mutation is significantly associated with the RNA expression of many other genes, with 4,916 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF1-associated genes across cancer lineages are RHBDD3, ECH1, and LRRC59. Each is linked with TAF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TAF1-to-partner and partner-to-TAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHBDD3 grouped by TAF1-low versus TAF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF1→partner) and Y-score (partner→TAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RHBDD3 →	+0.432	+2.604	.004	<.001	3	4
UCEC	ECH1 →	+0.193	+1.397	.008	<.001	3	4
SKCM	LRRC59 →	+0.396	+2.497	.007	.009	3	4
SKCM	ZBTB17 →	+0.347	+3.472	.004	.002	3	4
LUAD	TUBG1 →	+0.574	+3.459	.006	.005	2	5
UCEC	AURKB →	+0.432	+1.185	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,916 associations by consensus.

RHBDD3 by TAF1 expression — SKCM

Explore this box plot interactively →