TAF1

Across TCGA patient cohorts, TAF1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAF1-associated genes across cancer lineages are RAD51, Cyclin-B1, and MYH11. Each is linked with TAF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TAF1-to-partner and partner-to-TAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by TAF1-low versus TAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF1→partner) and Y-score (partner→TAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.067	+1.000	.023	.013	3	4
UCEC	Cyclin-B1 →	+0.491	+1.222	<.001	<.001	3	4
SKCM	MYH11 →	-0.965	-3.321	.009	.009	3	4
UCEC	MEK1 →	+0.332	+1.222	<.001	<.001	3	3
LUAD	PAI-1 →	+1.002	+3.000	.007	.036	1	5
COAD	Shc_pY317 →	-0.173	-2.983	.013	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

RAD51 by TAF1 expression — UCEC

Explore this box plot interactively →