TADA2B

Across TCGA patient cohorts, TADA2B mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TADA2B-associated genes across cancer lineages are Annexin-1, VEGFR2, and BRD4. Each is linked with TADA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TADA2B-to-partner and partner-to-TADA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TADA2B-low versus TADA2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TADA2B→partner) and Y-score (partner→TADA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.978	+3.019	<.001	.019	3	1
UCEC	VEGFR2 →	+0.327	+3.183	.045	.010	3	1
UCEC	BRD4 →	+0.439	+3.010	.002	.019	3	1
UCEC	JNK2 →	+0.508	+3.009	<.001	.019	2	1
UCEC	4E-BP1 →	+0.579	+3.029	<.001	.018	2	1
UCEC	Fibronectin →	-0.420	-3.169	.020	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Annexin-1 by TADA2B expression — UCEC

Explore this box plot interactively →