TADA2A

Across TCGA cell cohorts, TADA2A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TADA2A-associated genes across cancer lineages are SIGLECL1, OR11L1, and LCE2C. Each is linked with TADA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TADA2A-to-partner and partner-to-TADA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLECL1 grouped by TADA2A-low versus TADA2A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TADA2A→partner) and Y-score (partner→TADA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLECL1 →	+0.027	+5.562	<.001	<.001	3	1
LUNG_SCLC	OR11L1 →	+0.055	+4.643	<.001	.004	3	1
CNS	LCE2C →	+0.044	+4.754	<.001	.005	3	1
CNS	HELT →	+0.030	+4.321	<.001	.009	3	1
LUNG_SCLC	BMP10 →	+0.156	+4.044	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SIGLECL1 by TADA2A expression — LARGE_INTESTINE

Explore this box plot interactively →