TACR1

Across TCGA patient cohorts, TACR1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACR1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with TACR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TACR1-to-partner and partner-to-TACR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by TACR1-low versus TACR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACR1→partner) and Y-score (partner→TACR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.432	+2.179	.045	.034	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.430	-1.687	.024	.044	3	2
UCEC	PDCD4 →	-0.555	-1.700	.005	.044	3	2
SKCM	ETS-1 →	-0.364	-3.000	.016	.035	3	1
UCEC	ERK2 →	+0.181	+1.700	.026	.044	3	1
UCEC	FOXO3a_pS318_S321 →	-0.143	-2.222	.007	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Acetyl-a-Tubulin-Lys40 by TACR1 expression — UCEC

Explore this box plot interactively →