TACR1

Across TCGA pan-cancer cohorts, TACR1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TACR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TACR1 RNA is repressed in tumor relative to normal tissue. In most cancer types TACR1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and HNSC are the cancer types where TACR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TACR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.525	<.001	11	view →
KIRC	Male	IV	−1.467	<.001	11	view →
HNSC	Male	IV	−1.325	<.001	11	view →
BLCA	Male	All	−1.654	<.001	10	view →
KIRP	All	II,III,IV	−1.065	<.001	9	view →
COAD	Male	All	−0.700	<.001	8	view →
BRCA	All	III,IV	−2.413	<.001	6	view →
UCEC	All	All	−2.147	<.001	6	view →
LUAD	All	II,III,IV	−0.653	<.001	6	view →
LUSC	Male	II,III,IV	−1.040	<.001	5	view →
STAD	All	All	−0.644	<.001	5	view →
LIHC	All	All	+0.144	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TACR1–KICH

Open the KICH breakdown →