TACR1

Across TCGA cell cohorts, TACR1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TACR1-associated genes across cancer lineages are ADAM30, CYP11B1, and CCDC140. Each is linked with TACR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TACR1-to-partner and partner-to-TACR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM30 grouped by TACR1-low versus TACR1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACR1→partner) and Y-score (partner→TACR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADAM30 →	+0.006	+4.212	.008	.007	3	1
LUNG_NSCLC_LUAD	CYP11B1 →	+0.011	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	CCDC140 →	+0.303	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.044	+5.472	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ADAM30 by TACR1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →