TACC3

Across TCGA patient cohorts, TACC3 mutation is significantly associated with the RNA expression of many other genes, with 2,751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACC3-associated genes across cancer lineages are CTNNAL1, TYMSP1, and IQCF5-AS1. Each is linked with TACC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TACC3-to-partner and partner-to-TACC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTNNAL1 grouped by TACC3-low versus TACC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC3→partner) and Y-score (partner→TACC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTNNAL1 →	+0.700	+2.365	<.001	.002	3	3
HNSC	TYMSP1 →	+0.058	+6.468	<.001	.001	3	2
SKCM	IQCF5-AS1 →	+0.007	+2.555	<.001	.006	3	2
SKCM	RN7SL554P →	+0.039	+2.877	<.001	.009	3	2
CESC	OR4K11P →	+0.073	+7.584	<.001	<.001	3	2
UCEC	MIR3661 →	+0.708	+2.116	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,751 associations by consensus.

CTNNAL1 by TACC3 expression — UCEC

Explore this box plot interactively →