TACC3

Across TCGA pan-cancer cohorts, TACC3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TACC3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TACC3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TACC3 is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where TACC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TACC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.687	<.001	12	view →
KIRC	Male	IV	+1.454	<.001	12	view →
BLCA	Male	III,IV	+2.552	<.001	11	view →
KIRP	All	III,IV	+1.598	<.001	11	view →
COAD	Female	II,III,IV	+1.198	<.001	11	view →
LIHC	Female	II,III,IV	+2.434	<.001	9	view →
LUAD	Male	III,IV	+1.876	<.001	9	view →
UCEC	All	II,III,IV	+3.371	<.001	8	view →
STAD	Female	All	+2.458	<.001	8	view →
LUSC	Female	II,III,IV	+2.225	<.001	8	view →
BRCA	All	III,IV	+1.872	<.001	6	view →
CHOL	Male	All	+3.461	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TACC3–HNSC

Open the HNSC breakdown →