TACC3

Across TCGA cell cohorts, TACC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,562 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TACC3-associated GO terms across cancer lineages are Nuclear chromosome segregation, Sister chromatid segregation, and Mitotic sister chromatid segregation. Each is linked with TACC3 in more than 19 cancer types. Because this analysis shows association rather than direction, both TACC3-to-partner and partner-to-TACC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear chromosome segregation grouped by TACC3-low versus TACC3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC3→partner) and Y-score (partner→TACC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Nuclear chromosome segregation →	+0.153	+1.328	.001	<.001	3	20
BONE	Sister chromatid segregation →	+0.124	+1.336	.002	.002	3	20
OESOPHAGUS	Mitotic sister chromatid segregation →	+0.128	+0.894	.001	.002	3	20
OESOPHAGUS	Chromosome segregation →	+0.136	+1.170	.001	<.001	3	20
LUNG_NSCLC_LUSC	Microtubule cytoskeleton organization involved in mitosis →	+0.094	+1.171	.003	.003	3	20
OESOPHAGUS	Positive regulation of chromosome condensation →	+0.242	+1.201	.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,562 associations by consensus.

Nuclear chromosome segregation by TACC3 expression — OESOPHAGUS

Explore this box plot interactively →