TACC3

Across TCGA cell cohorts, TACC3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TACC3-associated genes across cancer lineages are RIPPLY1, TARM1, and OR4F6. Each is linked with TACC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TACC3-to-partner and partner-to-TACC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIPPLY1 grouped by TACC3-low versus TACC3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC3→partner) and Y-score (partner→TACC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIPPLY1 →	+0.021	+3.269	.001	.007	3	2
URINARY_TRACT	TARM1 →	+0.026	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	OR4F6 →	+0.019	+5.209	<.001	.005	3	1
SKIN	AKAP4 →	+0.011	+3.684	<.001	.006	3	1
SKIN	PDCL2 →	+0.409	+3.930	<.001	.003	3	1
SKIN	AMY2A →	+0.046	+3.930	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RIPPLY1 by TACC3 expression — BLOOD_Leukemia

Explore this box plot interactively →