TACC2

Across TCGA patient cohorts, TACC2 mutation is significantly associated with the RNA expression of many other genes, with 8,647 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACC2-associated genes across cancer lineages are GTF2E2, DOHH, and CEP55. Each is linked with TACC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TACC2-to-partner and partner-to-TACC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTF2E2 grouped by TACC2-low versus TACC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC2→partner) and Y-score (partner→TACC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GTF2E2 →	+0.463	+1.436	<.001	<.001	3	6
UCEC	DOHH →	+0.401	+1.727	<.001	<.001	3	5
UCEC	CEP55 →	+0.492	+1.536	.001	.001	3	5
STAD	SOD1 →	+0.511	+2.321	<.001	.006	3	5
SKCM	EBP →	+0.199	+1.175	.008	<.001	3	5
STAD	MRPL39 →	+0.595	+3.033	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,647 associations by consensus.

GTF2E2 by TACC2 expression — UCEC

Explore this box plot interactively →