TACC2

Across TCGA pan-cancer cohorts, TACC2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TACC2’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TACC2 RNA is repressed in tumor relative to normal tissue. In most cancer types TACC2 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and LIHC are the cancer types where TACC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TACC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.528	<.001	11	view →
THCA	Male	III,IV	−1.652	<.001	10	view →
LIHC	Female	II,III,IV	+1.088	<.001	9	view →
BRCA	Female	II,III,IV	−0.378	<.001	6	view →
CHOL	Female	All	+2.170	<.001	5	view →
COAD	Female	II,III,IV	−0.441	<.001	5	view →
KIRC	Male	II,III,IV	−0.436	.006	5	view →
KICH	All	II,III,IV	+0.744	.001	4	view →
LUSC	All	All	−0.559	<.001	4	view →
PAAD	Male	All	+0.910	.011	2	view →
UCEC	All	All	−0.797	.004	2	view →
LUAD	All	All	−0.694	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TACC2–BLCA

Open the BLCA breakdown →