TACC2

Across TCGA patient cohorts, TACC2 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TACC2-associated genes across cancer lineages are PRDX1, ATM, and GAPDH. Each is linked with TACC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TACC2-to-partner and partner-to-TACC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by TACC2-low versus TACC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC2→partner) and Y-score (partner→TACC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRDX1 →	+0.346	+3.186	.008	.009	3	4
UCEC	ATM →	-0.503	-1.700	<.001	<.001	3	4
SKCM	GAPDH →	+0.305	+0.898	.027	.011	3	3
SKCM	4E-BP1_pT70 →	+0.111	+1.369	.009	.002	3	3
COAD	INPP4B →	-0.460	-3.459	.001	.005	3	3
COAD	PAI-1 →	+0.639	+2.123	.006	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

PRDX1 by TACC2 expression — LUAD

Explore this box plot interactively →