TACC2

Across TCGA cell cohorts, TACC2 mutation is significantly associated with the RNA expression of many other genes, with 1,956 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TACC2-associated genes across cancer lineages are PSMB6, TTK, and GID4. Each is linked with TACC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TACC2-to-partner and partner-to-TACC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by TACC2-low versus TACC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC2→partner) and Y-score (partner→TACC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSMB6 →	+0.530	+2.789	.005	.001	3	4
LARGE_INTESTINE	TTK →	+0.541	+2.130	<.001	<.001	3	4
BLOOD_Leukemia	GID4 →	+0.655	+3.290	<.001	.003	3	3
LARGE_INTESTINE	KRR1 →	+0.739	+3.169	.001	.006	3	3
LARGE_INTESTINE	SDHB →	+0.504	+3.502	<.001	<.001	3	3
BLOOD_Leukemia	TCP1 →	+0.555	+3.321	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,956 associations by consensus.

PSMB6 by TACC2 expression — BLOOD_Leukemia

Explore this box plot interactively →