TACC1

Across TCGA cell cohorts, TACC1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TACC1-associated genes across cancer lineages are EFCAB3, TAS2R39, and OR2AK2. Each is linked with TACC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TACC1-to-partner and partner-to-TACC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EFCAB3 grouped by TACC1-low versus TACC1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TACC1→partner) and Y-score (partner→TACC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EFCAB3 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	1
OVARY	OR2AK2 →	+0.062	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	DAZL →	+0.027	+4.212	<.001	.007	3	1
LARGE_INTESTINE	TCF15 →	+0.408	+3.878	.003	.003	3	1
LARGE_INTESTINE	DIRC1 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EFCAB3 by TACC1 expression — OESOPHAGUS

Explore this box plot interactively →