TAC4

Across TCGA cell cohorts, TAC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,683 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TAC4-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Pre-mRNA catabolic process, and Positive regulation of double-strand break repair. Each is linked with TAC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both TAC4-to-partner and partner-to-TAC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by TAC4-low versus TAC4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TAC4→partner) and Y-score (partner→TAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.105	+0.230	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Pre-mRNA catabolic process →	+0.120	+0.196	.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.062	+0.177	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription elongation by RNA polymerase II →	+0.113	+0.177	<.001	.001	3	7
LARGE_INTESTINE	Negative regulation of chromosome condensation →	+0.102	+0.187	.002	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Microtubule nucleation →	+0.087	+0.188	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,683 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by TAC4 expression — LARGE_INTESTINE

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