TAC4

Across TCGA pan-cancer cohorts, TAC4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TAC4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TAC4 RNA is repressed in tumor relative to normal tissue. In most cancer types TAC4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where TAC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.346	<.001	7	view →
LIHC	All	All	+0.165	<.001	7	view →
KICH	All	All	−0.175	.006	4	view →
CHOL	All	All	+0.711	.001	3	view →
HNSC	All	All	+0.231	.014	3	view →
LUAD	All	All	+0.481	.007	2	view →
PRAD	All	All	+0.143	.047	2	view →
KIRC	All	All	+0.093	.009	2	view →
STAD	All	IV	−0.380	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TAC4–THCA

Open the THCA breakdown →