TAC3

Across TCGA cell cohorts, TAC3 protein abundance is significantly associated with the go_rna of many other GO terms, with 883 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TAC3-associated GO terms across cancer lineages are Response to interleukin-18, Activation of Janus kinase activity, and Regionalization. Each is linked with TAC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TAC3-to-partner and partner-to-TAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-18 grouped by TAC3-low versus TAC3-high in PANCREAS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TAC3→partner) and Y-score (partner→TAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Response to interleukin-18 →	-0.217	-1.051	<.001	.005	3	4
PANCREAS	Activation of Janus kinase activity →	-0.978	-1.082	.009	.003	3	3
URINARY_TRACT	Regionalization →	+0.042	+2.360	.009	.002	3	3
LUNG_NSCLC_LUAD	Regulation of vascular endothelial growth factor production →	+0.211	+1.002	<.001	<.001	3	3
LUNG_NSCLC_LUAD	Positive regulation of vascular endothelial growth factor production →	+0.217	+1.108	<.001	<.001	3	3
LUNG_NSCLC_LUAD	Protein delipidation →	-0.081	-0.861	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 883 associations by consensus.

Response to interleukin-18 by TAC3 expression — PANCREAS

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