TAAR1

Across TCGA patient cohorts, TAAR1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAAR1-associated genes across cancer lineages are TFRC, PCNA, and CD274. Each is linked with TAAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAAR1-to-partner and partner-to-TAAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TAAR1-low versus TAAR1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAAR1→partner) and Y-score (partner→TAAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TFRC →	+0.892	+3.009	.012	.019	3	2
UCEC	PCNA →	+0.216	+2.321	.046	.035	3	2
LUSC	CD274 →	+1.052	+3.015	.001	.018	3	1
UCEC	Ku80 →	+0.257	+2.335	.030	.020	3	1
UCEC	Myosin-IIa_pS1943 →	+0.225	+2.335	.029	.020	3	1
UCEC	Notch1 →	+0.241	+3.013	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

TFRC by TAAR1 expression — LUSC

Explore this box plot interactively →