TAAR1

Across TCGA pan-cancer cohorts, TAAR1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TAAR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TAAR1 RNA is repressed in tumor relative to normal tissue. In most cancer types TAAR1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and HNSC are the cancer types where TAAR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAAR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.330	<.001	7	view →
KIRP	Male	All	−0.189	<.001	5	view →
HNSC	All	All	−0.116	.005	4	view →
THCA	Male	III,IV	−0.082	.014	4	view →
UCEC	All	All	−0.592	.004	2	view →
PRAD	All	All	−0.239	.006	2	view →
STAD	Male	IV	−0.449	.004	1	view →
KIRC	All	IV	−0.153	.020	1	view →
LUSC	Female	III,IV	−0.095	.002	1	view →
LUSC	All	All	+0.051	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

TAAR1–KICH

Open the KICH breakdown →