SYVN1

Across TCGA pan-cancer cohorts, SYVN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYVN1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SYVN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SYVN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where SYVN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.256	0.545	.002	34	view →
CCRCC	OS	Median	All	0.629	1.000	.002	27	view →
HNSC	DFS	Tertile	All	0.767	0.545	.006	9	view →
UCEC	DFS	Tertile	All	0.793	0.969	.025	4	view →
LSCC	DFS	Median	III,IV	0.499	0.900	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYVN1–PDAC (OS)

Open the PDAC breakdown →