SYVN1

Across TCGA pan-cancer cohorts, SYVN1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SYVN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SYVN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYVN1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where SYVN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYVN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+0.886	<.001	12	view →
THCA	Male	III,IV	−0.882	<.001	10	view →
HNSC	All	III,IV	+0.609	<.001	10	view →
LIHC	All	III,IV	+0.740	<.001	9	view →
BLCA	Male	All	+0.670	<.001	9	view →
LUAD	Female	III,IV	+0.948	<.001	8	view →
STAD	All	II,III,IV	+0.807	<.001	6	view →
KIRP	All	II,III,IV	+0.453	.007	6	view →
LUSC	All	II,III,IV	+0.350	<.001	6	view →
BRCA	All	All	+0.193	<.001	6	view →
KICH	All	II,III,IV	+0.629	.002	5	view →
COAD	All	II,III,IV	+0.315	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SYVN1–KIRC

Open the KIRC breakdown →