SYVN1

Across TCGA patient cohorts, SYVN1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYVN1-associated genes across cancer lineages are MIG-6, PCNA, and GSK-3_pS9. Each is linked with SYVN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYVN1-to-partner and partner-to-SYVN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by SYVN1-low versus SYVN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYVN1→partner) and Y-score (partner→SYVN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.088	+2.817	.048	.036	3	2
UCEC	PCNA →	+0.318	+2.700	.001	.006	3	2
UCEC	GSK-3_pS9 →	-0.557	-3.321	.002	.010	3	1
UCEC	GSK-3a-b_pS21_S9 →	-0.515	-3.321	.007	.009	3	1
UCEC	HER3_pY1289 →	+0.112	+1.894	.003	.030	3	1
UCEC	IRS1 →	+0.275	+3.169	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MIG-6 by SYVN1 expression — UCEC

Explore this box plot interactively →