SYVN1

Across TCGA cell cohorts, SYVN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,890 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SYVN1-associated GO terms across cancer lineages are Endoplasmic reticulum to cytosol transport, Retrograde protein transport, ER to cytosol, and Protein exit from endoplasmic reticulum. Each is linked with SYVN1 in more than 17 cancer types. Because this analysis shows association rather than direction, both SYVN1-to-partner and partner-to-SYVN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to cytosol transport grouped by SYVN1-low versus SYVN1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYVN1→partner) and Y-score (partner→SYVN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Endoplasmic reticulum to cytosol transport →	+0.183	+0.919	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Retrograde protein transport, ER to cytosol →	+0.183	+0.919	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Protein exit from endoplasmic reticulum →	+0.167	+0.718	<.001	.006	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.134	+1.166	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Negative regulation of response to endoplasmic reticulum stress →	+0.112	+0.741	<.001	<.001	3	16
KIDNEY	Response to topologically incorrect protein →	+0.075	+0.894	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,890 associations by consensus.

Endoplasmic reticulum to cytosol transport by SYVN1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →