SYVN1

Across TCGA cell cohorts, SYVN1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYVN1-associated genes across cancer lineages are KCNK17, EPPIN, and APOL5. Each is linked with SYVN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYVN1-to-partner and partner-to-SYVN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK17 grouped by SYVN1-low versus SYVN1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYVN1→partner) and Y-score (partner→SYVN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCNK17 →	+0.034	+4.714	<.001	.002	3	2
BLOOD_Leukemia	EPPIN →	+0.005	+4.507	.001	.001	3	1
BLOOD_Leukemia	APOL5 →	+0.022	+4.060	<.001	.003	3	1
BLOOD_Leukemia	CYP39A1 →	+0.318	+3.769	<.001	.008	3	1
BLOOD_Leukemia	CCKAR →	+0.017	+4.824	.002	<.001	3	1
BLOOD_Leukemia	HTR1E →	+0.003	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

KCNK17 by SYVN1 expression — BLOOD_Lymphoma

Explore this box plot interactively →