SYTL4

Across TCGA cell cohorts, SYTL4 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYTL4-associated genes across cancer lineages are Epirubicin, Quizartinib, and Voxtalisib. Each is linked with SYTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYTL4-to-partner and partner-to-SYTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epirubicin grouped by SYTL4-low versus SYTL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYTL4→partner) and Y-score (partner→SYTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Epirubicin →	+0.624	+2.649	.024	.046	3	1
LARGE_INTESTINE	Quizartinib →	+0.370	+2.652	.021	.045	3	1
LARGE_INTESTINE	Voxtalisib →	+0.337	+2.652	.015	.045	3	1
LARGE_INTESTINE	Fludarabine →	+0.737	+2.649	.004	.046	1	2
LARGE_INTESTINE	Olaparib →	+0.402	+2.646	.031	.047	1	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.987	+2.646	.006	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Epirubicin by SYTL4 expression — LARGE_INTESTINE

Explore this box plot interactively →