SYTL4

Across TCGA pan-cancer cohorts, SYTL4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SYTL4 data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SYTL4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYTL4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

UVM, BRCA, and ACC are the cancer types where SYTL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.403	0.771	<.001	120	view →
BRCA	OS	Median	II,III,IV	0.940	0.884	<.001	84	view →
ACC	DFS	Median	All	0.188	0.662	<.001	74	view →
LAML	DFS	Median	All	0.189	0.535	<.001	48	view →
MESO	OS	Median	III,IV	0.297	0.537	.001	45	view →
KIRP	DFS	Median	III,IV	0.423	0.734	.004	27	view →
BLCA	OS	Median	II,III,IV	0.777	0.659	.008	19	view →
LUAD	DFS	Tertile	IV	1.000	0.300	.011	18	view →
SCLC	OS	Median	III,IV	0.325	0.592	.022	13	view →
SKCM	OS	Tertile	IV	0.614	0.138	.009	12	view →
LIHC	DFS	Quartile	III,IV	0.506	0.205	.010	12	view →
KICH	DFS	Quartile	II,III,IV	0.625	1.000	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SYTL4–UVM (DFS)

Open the UVM breakdown →