SYT8

Across TCGA pan-cancer cohorts, SYT8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SYT8 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SYT8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SYT8 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

HNSC, BLCA, and LUAD are the cancer types where SYT8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.013	0.757	<.001	36	view →
BLCA	DFS	Median	III,IV	1.000	0.265	.022	10	view →
LUAD	OS	Median	II,III,IV	0.156	0.682	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SYT8–HNSC (OS)

Open the HNSC breakdown →