SYT8

Across TCGA pan-cancer cohorts, SYT8 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SYT8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SYT8 RNA is repressed in tumor relative to normal tissue. In most cancer types SYT8 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where SYT8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYT8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−1.708	<.001	11	view →
COAD	Male	II,III,IV	+0.732	<.001	10	view →
THCA	Male	All	+0.512	<.001	7	view →
BRCA	Female	II,III,IV	−1.746	<.001	6	view →
STAD	Male	All	+1.659	.002	6	view →
UCEC	All	All	+0.695	.013	6	view →
KICH	Male	All	−0.253	<.001	6	view →
PAAD	All	All	+4.562	.007	4	view →
CHOL	All	All	+2.721	.009	3	view →
LUSC	Female	All	−1.084	.002	2	view →
PRAD	All	All	−0.792	<.001	2	view →
LUAD	Female	All	−0.755	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SYT8–HNSC

Open the HNSC breakdown →